ReviewJ Biol Regul Homeost Agents

. 2020 Jul-Aug;34(4 Suppl. 1):1-13. SPECIAL ISSUE: OZONE THERAPY.

Safety, pitfalls, and misunderstandings about the use of ozone therapy as a regenerative medicine tool. A narrative review

L Re 1J B Noci 2M E Gadelha Serra 3P Mollica 4M Bonetti 5V Travagli 6

Affiliations expand

  • PMID: 33176412


Despite various opinions and healthy controversy on Ozone Therapy (OT), the practices of this therapy have increased worldwide. Main areas of study with consistent scientific outcomes are the topical treatment of both disk herniation and periodontal disease. On the other hand, there is a net dissociation of the scientific resonance concerning systemic oxygen/ozone treatments. It is our intention to discuss in logical terms the numerous papers that commendably reported adverse reactions attributable to OT, focusing our attention mainly to the techniques of administration and not to the simple contact of ozone with biological material. The case reports on OT treatments safety concerns discussed on international journals, make it possible to state that most safety issues are secondary to infections or traumatic reactions due to malpractice. Commonly, the molecule of ozone itself is not responsible of severe reactions at the therapeutic modalities. The millions of patients treated so far from the thousands of physicians correctly practicing OT world widely in the last 40 years demonstrate the safety of this simple and cost-effective regenerative medicine tool. The promising therapeutic implications also for the current COVID-19 emergency are a further stimulus to the standardization of this therapeutic resource with multiple application specificities.

Keywords: drug management; drug safety; oxidative stress; ozone therapy; regenerative medicine; side effects.

Similar articles

See all similar articles

Cited by

Publication types

  • Review

MeSH terms

  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections / therapy
  • Humans
  • Ozone / therapeutic use*
    • Pandemics
    • Pneumonia, Viral / therapy
    • Regenerative Medicine / trends*
    • SARS-CoV-2


    • Ozone

    Related information

    LinkOut – more resources